Description

ANDROCTONUS AMOREUXI VENOM

We have characterized the immunological and pharmacological properties of the three major alpha-type toxins from the scorpion Androctonus amoreuxi, AamH1, AamH2 and AamH3, which were previously described as putative toxins from cDNAs [Chen, T. et al., 2003. Regul.

Pept. 115, 115-121]. The immunological tests (ELISA, RIA) have demonstrated that AamH1, AamH2 and AamH3 belong to the immunological groups 3 and 4 of alpha-type toxins. Analysis of the three toxin effects on currents through rat brain (rNav1.2), rat muscle (rNav1.4) and Drosophila (DmNav1) sodium channels expressed in Xenopus oocytes revealed that AamH1 and AamH2, but not AamH3, have anti-insect and anti-mammal activities and can be classified as alpha-like toxins.

While AamH1 removes fast inactivation only in neuronal rNav1.2 channel and has no effect on muscular rNav1.4 channel, AamH2 affects both neuronal rNav1.2 and muscular rNav1.4 channels. AamH3 was lethal to mice by intracerebroventricular injection despite its lack of activity on the neuronal rNav1.2 channel.

Finally, we have shown that the A. amoreuxi venom was better neutralized by the antiserum raised against the venom of Buthus occitanus tunetanus than by the antisera raised against scorpion venoms from the same genus Androctonus.

Scorpion Venom Function:

1. Neurogrowth hormone: It has broad application prospects in nerve molecules, molecular immunity, molecular evolution, protein structure and function.

2. Thrombolytic factor: It has the effect of preventing thrombosis and dissolution of thrombus, and it has certain therapeutic effect on coronary heart disease and myocardial infarction caused by various embolism.

3. Vascular Polypeptide: This can effectively soften the blood vessels and remove the inner wall of the blood vessels and fixtures. Effective prevention and treatment of coronary heart disease, heart failure, myocardial infarction, arteriosclerosis, senile dementia.

4. Anticancer Polypeptide: Anticancer peptides can effectively kill cancer cells. The Active Ingredient, you can also visit our SHOP for more venoms and prices.